What Is Bromide Toxicity?

Knowledge is power; it can lead you down the path towards a vibrant and cancer-free life. A study by Woody et al. (79) showed that, in human patients, the degree of pseudohyperchloremia could be used as an indirect method to assess bromide serum concentration in a quicker manner (79). Inspired by these results, Rossmeisl et al. (77) studied the existence of a possible similar relationship between the magnitude of pseudohyperchloremia and bromide serum concentration in bromide treated epileptic dogs. Rossmeisl et al. (77) concluded that in dogs this relationship was unsatisfactory for routine use in practice and bromide dose adjustments should be based on the direct assessment of bromide serum concentration.

Short-Term Treatment

Serum level monitoring also allows the clinician to determine if medication failure is related to metabolic tolerance (in patients requiring dose adjustment) or functional tolerance (in patients requiring a change of medications). It helps monitoring owner’s compliance and prevent possible toxic effects (75). Bromide serum concentration monitoring is indicated in patients receiving treatment with this medication. Adequate monitoring allows individualization and optimization of treatment due to the narrow therapeutic ranges and known pharmacokinetic variability between individuals (52).

Iodine Detox Symptoms: Here’s What You Should Know (

Temporary feelings of low mood or depression can be a result of iodine detox processes. People choose iodine detox for various reasons, primarily related to potential health benefits. Iodine is believed to play bromide detox a crucial role in supporting thyroid health, metabolism, and overall well-being. Exposure to even small amounts over time can accumulate in the body, leading to disruptions in thyroid function, oxidative stress, and hormonal imbalances.

Initially met with skepticism, bromide quickly gained enthusiasm within the medical field until being largely replaced by newer antiseizure medications with significantly fewer adverse effects in people. In veterinary medicine, bromide continues to be used in the management of epileptic patients for over 30 years, yet adverse effects can impact owners and patients alike. It’s also our endeavor to discuss the current use as an alternative or add-on with other known antiseizure medications and potential future studies that might enhance our understanding and use of this medication. Since bromide is eliminated by the kidneys, renal disease can lead to an inappropriate rise in bromide serum concentration and consequent bromide toxicity (50).

What Are the Sources of Bromine?

• It’s important to note that not everyone may experience these symptoms, and they are typically transient as the body adjusts.
• It is widely knowledge that seafood and deep sea plants have higher levels than dry land meals.
• With Level 3 Testing, you can order a testing kit that is used to prepare your sample and submit it to the lab.
• Additionally, a 20–30% of epileptic dogs are refractory to treatment (23, 27, 93, 94), a phenomenon also observed in human medicine (95).

The combination of bromide with levetiracetam did not result in any significant recorded pharmacokinetic interaction. This contrasted with the combination of phenobarbital (alone or in association with bromide) with levetiracetam, which led to an increased clearance and lower levetiracetam plasma concentrations (86). The current recommended therapeutic bromide serum concentrations are based in only a few previous studies on the use of this medication (23, 26, 27). The end result of a loading dose can be assessed 1 week after the administration of a loading dose protocol.

Notes on Level 4 Testing for Bromide

• It’s also our endeavor to discuss the current use as an alternative or add-on with other known antiseizure medications and potential future studies that might enhance our understanding and use of this medication.
• The human body has natural detoxification capabilities, but heavy exposure to environmental toxins like bromide can overwhelm these systems.
• It is essential to approach iodine detox with caution and seek professional guidance, as excessive iodine intake can have adverse effects on thyroid function and overall health.
• In organic synthesis, EtBr serves as a stand-in for the ethyl carbocation (Et+) synthon.

It is well tolerated, has a widespread availability and low cost, making it the primary treatment choice in canine epilepsy (10, 11). In addition to phenobarbital, imepitoin and potassium bromide are the only approved ASM for the treatment of canine epilepsy in Europe (11). The use of primidone, levetiracetam, zonisamide, felbamate, topiramate, gabapentin, pregabalin is also described, although the levels of evidence supporting their efficacy vary considerably (13). Bromide toxicity is a condition that occurs when a person is exposed to high levels of bromide, either through ingestion, inhalation, or skin contact. Bromide is a chemical that is used in a variety of industrial and commercial products, including flame retardants, insecticides, and disinfectants.

You probably haven’t heard too much about fluoride’s sister toxin, bromide, however. The fact that so little is known about this volatile chemical compound within the general public makes its side effects all the more mysterious ─ and insidious. Bromine is present in seawater at a concentration of 65 milligrams per liter. Bromide exhibits its most significant and well-known interaction with chloride, which in turn is influenced by the patient’s diet. Diets with higher chloride content may result in faster elimination of bromide (87).

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If your test results reveal the presence of a contaminant that is cause for concern, you can either proceed to determine the best treatment (see below) or continue to Level 3 Testing. Level 1 Testing is done with simple observations that an individual can make with their own senses such as sight, smell, and taste. These observations can be readily apparent or can be observed as they change over time. In addition, accessible related information about the home can also be used to narrow down the cause of your water issues. A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose.

– Iodine Can Help Your Body Detox from Halides (Fluoride, Bromide, and Chlorine)

Trepanier and Babish (87) suggested that the predicted mean daily doses of bromide needed to maintain an adequate serum concentration were significantly higher for patients with higher chloride content in their diet (87). For this reason, there is a general recommendation for the ingestion of chloride to be maintained constant in human and veterinary patients receiving treatment with bromide (87, 88). Dogs with adequate seizure control can experience recurrence of seizures after a sudden increase in chloride intake through a diet change and consequent drop in serum bromide concentrations (89). Treating bromide toxicity typically involves supportive care to address symptoms and remove excess bromide from the body. This may include medications to control seizures, fluids to prevent dehydration, and medications to improve breathing. In severe cases, dialysis may be necessary to remove excess bromide from the blood.

Bromide detox? Or just sick?

It is important to report to the healthcare provider as soon as possible if a person suspects they may have been exposed to high levels of bromide. The specific treatment will depend on the amount and duration of exposure, as well as the individual’s symptoms and overall health. Evidence regarding the frequency of polyuria and polydipsia (Pu/Pd) in dogs treated with bromide is controversial. Podell and Fenner (23) reported Pu/Pd in 13 out of 23 dogs receiving potassium bromide in combination with phenobarbital (23).

Bromine works by releasing oxygen-free radicals or nascent oxygen from oxygen in the mucous membrane. While discussing the case of bromism in the paper, the authors explained that ChatGPT and other AI tools could sometimes give wrong scientific information. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. GABA release, binding, transport or metabolism, however, does not appear to be affected by acute or chronic exposure to bromide (34).

If you are on a private system and the water has a salty taste, it is possible that your source is impacted by a saline water source. In this case, we suggest a comprehensive water quality check and that you use an alternative water source for consumption. In the short term for low levels of bromide, we might consider a combination of a point-of-use filtration system and a point-of-use Reverse Osmosis system. Excessive iodine intake can lead to adverse effects on thyroid function and other health complications.